Antigen-reactivity pattern of T-cell hybridomas from Mycobacterium bovis BCG-infected mice

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Antigen-reactivity pattern of T-cell hybridomas from Mycobacterium bovis BCG-infected mice.

Lymph node cells from mice infected with live Mycobacterium bovis BCG were fused with BW5147 cells after short-term culturing in vitro. Both mycobacterium- and self-reactive T-cell hybridomas were identified. Some T-cell hybridoma clones displayed dual reactivity to self and to self plus mycobacterial antigen but did so to a different degree, indicating that infection with mycobacteria stimulat...

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It has previously been reported that inhibition of delayed-type hypersensitivity-mediating functions of T cells during mycobacterial infection in mice is haplotype dependent. In the present study, we show that Mycobacterium bovis BCG infection induced, in susceptible C57BL/6 and BALB/c mice but not in resistant C3H/HeJ and DBA/2 mice, an important splenomegaly. An in vitro defect in T-cell prol...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1985

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.49.3.838-840.1985